The immune response of hamsters to purified haemagglutinins and whole influenza virus vaccines following live influenza virus infection
Identifieur interne : 002C17 ( Main/Exploration ); précédent : 002C16; suivant : 002C18The immune response of hamsters to purified haemagglutinins and whole influenza virus vaccines following live influenza virus infection
Auteurs : R. Jennings ; C. M. Brand [Royaume-Uni] ; C. Mclaren ; Lynda Shepherd ; C. W. PotterSource :
- Medical Microbiology and Immunology [ 0300-8584 ] ; 1974-11-01.
English descriptors
- Teeft :
- Antibody, Antibody response, Antibody titres, Detectable serum, Enhancement, Haemagglutinin, Haemagglutinin antigens, Haemagglutinins, Hamster, Heterotypic, Hong kong, Immune response, Immunization, Influenza, Influenza vaccines, Influenza virus, Influenza viruses, Split vaccine, Subsequent immunization, Titration vaccine, Vaccine, Vaccine virus, Virus, Whole virus vaccine.
Abstract
Abstract: The ability of several, live type A influenza viruses to enhance the serum haemagglutination-inhibiting (HI) antibody response of hamsters to subsequent immunization with inactivated, heterotypic influenza virus vaccines was examined. Live influenza viruses were found to vary in their priming ability for a given vaccine, and a given virus was not able to prime for all inactivated vaccines to an equal extent. Common determinants in the haemagglutinin antigens of the priming virus and the vaccine virus were suggested as responsible for the enhancement of the antibody response to some of the vaccines, but for other pairs of viruses the haemagglutinin antigens were distinct. Thus, enhancement in these instances cannot be due to cross-reacting haemagglutinins. Pre-infection of hamsters by several influenza type A viruses was employed in an attempt to enhance the serum HI antibody response to purified, haemagglutinin antigens prepared from A/PR/8/34 and the MRC-2 recombinant strain of A/England/42/72 viruses. Although prior infection enhanced the antibody response to whole virus, this was not demonstrable for the purified haemagglutinin components of the virus. The possible reasons for this are discussed.
Url:
DOI: 10.1007/BF02121445
Affiliations:
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Le document en format XML
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Live influenza viruses were found to vary in their priming ability for a given vaccine, and a given virus was not able to prime for all inactivated vaccines to an equal extent. Common determinants in the haemagglutinin antigens of the priming virus and the vaccine virus were suggested as responsible for the enhancement of the antibody response to some of the vaccines, but for other pairs of viruses the haemagglutinin antigens were distinct. Thus, enhancement in these instances cannot be due to cross-reacting haemagglutinins. Pre-infection of hamsters by several influenza type A viruses was employed in an attempt to enhance the serum HI antibody response to purified, haemagglutinin antigens prepared from A/PR/8/34 and the MRC-2 recombinant strain of A/England/42/72 viruses. Although prior infection enhanced the antibody response to whole virus, this was not demonstrable for the purified haemagglutinin components of the virus. 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